Yin Shen, Ph.D.
Professor at the Institute for Human Genetics and the Department of Neurology
University of California, San Francisco
Seminar Information
Genome organization and transcriptomic profiles undergo extensive remodeling during human brain development. However, the developmental dynamics of the 3D epigenome and how they shape transcriptomic diversity and cellular function remain incompletely understood. In this talk, I will present how the 3D epigenome is dynamically rewired to regulate gene expression and RNA splicing during cortical development. I will also discuss how we apply functional genomic tools to dissect the roles of disease-associated genetic variants at base-pair resolution.
Dr. Yin Shen is a professor at the Institute for Human Genetics and the Department of Neurology at the University of California, San Francisco. She obtained a B.S. degree in Biological Sciences and Technologies from Nanjing University in China and a Ph.D. degree in Human Genetics from UCLA before completing postdoctoral training in Dr. Bing Ren’s
laboratory at the Ludwig Institute for Cancer Research and UCSD. Dr. Shen joined UCSF in 2015.
The Shen lab at UCSF is dedicated to investigating how 3D epigenome and non-coding sequences contribute to gene regulation, development, and diseases. They particularly focus on leveraging 3D genome information to understand gene regulatory controls in brain development and to prioritize disease-associated variants for functional studies. Additionally, the Shen lab develops and applies novel CRISPR approaches for characterizing candidate cis-regulatory elements and disease-associated variants in iPSC models. Dr. Shen has been an active member of the ENCODE and the 4D Nucleome consortium, contributing to the annotation of non-coding regulatory sequences in the human genome.