Mitochondrial Membrane Lipids and Respiratory Efficiency

Katsu Funai, Ph.D.

Associate Professor

Diabetes & Metabolism Research Center

University of Utah

Seminar Information

Seminar Date
May 13, 2022 - 2:00 PM

PFBH FUNG Auditorium and via Zoom

Katsu Funai


Mitochondrial oxidative phosphorylation (OXPHOS) consists of a series of processes that takes place in the inner mitochondrial membrane (IMM). Energy flux through OXPHOS appears to be intrinsically modulated by the lipid composition of IMM by mechanisms that are not clearly understood. In particular, phosphatidylethanolamine (PE) and cardiolipin (CL) are cone-shaped non-bilayer lipids that induce membrane curvature in cristae that may regulate OXPHOS efficiency. We are systematically examining the mitochondrial membrane lipid composition across mammalian tissues to elucidate their roles in adapting to altering energy demand and/or supply.


Speaker Bio

Katsu Funai is an Associate Professor at the Diabetes & Metabolism Research Center at the University of Utah. Dr. Funai’s lab has been continuously funded by NIH to study the role of lipids in bioenergetics. Originally from Japan, he received his BS/MS at Boston University and Ph.D. at the University of Michigan. He then completed his postdoctoral fellowship in Clay Semenkovich’s lab at Washington University in St. Louis to study de novo lipogenesis. In 2013, he opened his lab at East Carolina University and moved to the University of Utah in 2017.