MRS Metabolic Imaging – Noninvasive Detection of Tumor Development and Response

Friday, October 30, 2015 - 2:00pm
Fung Auditorium, Powell-Focht Bioengineering Hall
Sabrina Ronen, PhD

Professor in Residence
Department of Radiology
University of California, San Francisco

MRS Metabolic Imaging – Noninvasive Detection of Tumor Development and Response


Cellular metabolic reprogramming is increasingly viewed as a hallmark of cancer. Magnetic resonance spectroscopy (MRS) is a translational noninvasive imaging method that can be used to probe metabolism in vitro, in tissue samples, cells, animals and patients. We have used MRS in the preclinical setting to monitor the metabolic reprogramming that occurs in cancer and to inform on tumor development and response to therapy. The seminar will present recent work using MRS to characterize and image tumors, focusing on the metabolic reprogramming of mutant IDH1 glioma cells and the early monitoring of glioma response to novel therapies.


Sabrina M. Ronen is a Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Ronen completed her PhD in Chemical Physics from the Weizmann Institute of Science in Rehovot, Israel. She then trained as a postdoctoral fellow at the Institut Curie in Paris, France, and started her academic career at the Institute of Cancer Research in London, England. Dr. Ronen’s Laboratory focuses on developing and mechanistically validating robust non-invasive translatable MR–based biomarkers that can be used to monitor oncogenic transformation and response to therapy.