About

University of California San Diego Bioengineering PFBH (EBU3A)

"To improve health and quality of life by applying engineering principles to scientific discovery and technology innovation, and to train future leaders in Bioengineering through inspiring education and dedicated mentorship."

Bioengineering, one of the youngest engineering disciplines, employs the principles and tools of engineering to analyze and solve biological and medical problems. It is broad in its spectrum, with its foundation in all of the traditional engineering sciences, as well as biology, physiology and other biomedical sciences. UC San Diego is at the forefront of bioengineering. In recognition of the unique features and requirements of bioengineering and the excellence of the Bioengineering faculty and programs, the University of California established a Department of Bioengineering in August 1994. In 1995, the National Research Council of the National Academy of Science, National Academy of Engineering and the Institute of Medicine published a comprehensive report in which they ranked the UCSD Bioengineering graduate program number 1 in the nation for effectiveness in teaching and number 2 for scholarly quality. It remains the #1 ranked Bioengineering doctoral program according to the most recent National Research Council study (2010). The 2015 U.S News & World Report ranked our graduate program #2 and our undergraduate program #7 in the nation. At UCSD, the cooperative arrangement between the Schools of Engineering and Medicine is the foundation of this success by providing an ideal research and training environment that leads to effective collaborations between engineers and medical scientists. We broadly categorize our research interests to embrace three pillars of bioengineering: multiscale bioengineering, tissue engineering and regenerative medicine, and systems biology and medicine. With established and promising up-and-coming core faculty, our department has four disease focus areas including cancer, cardiovascular diseases, metabolic disorders, and neurodegenerative diseases.

 

Bioengineering Time Line 

 

 

2010s

2019
2018
2017
 
 
2016

Identification of three metabolic phenotypes in red cells during cold storage
Bordbar, A., Palsson, B. 0., et al


Identification of therapeutic targets for glioblastoma by network analysis (a systems level cure for gliblastoma?)
Friedman-Morvinski, Bhargava, Gupta, Verma, Su bramaniam


Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery
Kar, M., Vernon Shih, Y. R., Velez, D. 0., Cabrales, P., Varghese, S.


Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat
Buono, M. J., Krippes, T., Kolkhorst, F. W., Williams, A. T., Cabrales, P.


Inflammatory response to implantation of transparent nanocrystalline yttria­stabilized zirconia using a dorsal window chamber model
Damestani, Y., Galan-Hoffman, D. E., Ortiz, D., Cabrales, P., Aguilar, G.


2015

 

New Bioengineering Faculty Dr. Elliot McVeigh


 

New Bioengineering Faculty Dr. Bruce Wheeler


Initiation of clinical trial with regenerative hydrogel in myocardial infarction patients
Dr. Karen Christman


Perfusion pressure and blood flow determine microvascular apparent viscosity.
Yalcin 0, Ortiz D, Williams AT, Johnson PC, and Cabrales P.


Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice
Stobdan T, Ao-leong E, Ortiz D, McCulloch AD, Bafna V, Cabrales P, and Haddad GG.


Supra-plasma expanders: treating blood loss and anemia without red b lood cell transfusions
Tsai, A. G., Salazar Vazquez, B. Y., Hofmann, A., Acharya, S. A., lntaglietta, M.


Model driven discovery of underground metabolism
Guzman, G., Palsson, B.0. , et al


Cell type-restricted expression of E-Tmod41 and its localization to the dendrilic spine of horizontal cells in the reli na
Yao, W., Chu, X., Sung, L. A.


The first high-resolution dry-electrode mobile brain-computer interface for real­lime neuroimaging and cognitive monitoring
Mullen, T. R., Kothe, C. A. E., Chi, Y. M., Ojeda, A., Kerth, T., Makeig, S., Jung, T-P, Cauwenberghs, G.


Half a unit bood trasnfusion Is better than two units
lntaglietta, M.


Definition of the minimal proteome
Yang, L., Palsson, B.0. , et al


Systems vaccinology (the first multi-year multi-omics study of human response to influenza vaccine - highlight in Press as an important study for vaccination of the elderly)
Nakaya, Hagan, ...... Subramaniam, Pulendran


Biomarkers of NAFLD progression (the first serum biomarkers to discriminate liver pathologies)
Gorden, ..... Subramaniam, Brown


Control of overweight and obesity in childhood through education in meal time habits. The ·good manners for a healthy future· programme
Salazar Vazquez BY, Salazar Vazquez MA, Lopez Gutierrez G, Acosta Rosales K, Cabrales P, Vadillo-Ortega F, lntaglietta M, Perez Tamayo R, Schmid-Schonbein GW.

2014

 

New Bioengineering Faculty Dr. Stephanie Fraley


 

New Bioengineering Faculty Dr. Prashant Mali


Localized increase of tissue oxygen tension by magnetic targeted drug delivery.
Uong C, Ortiz D, Ao-ieong E, Navati MS, Friedman JM, and Cabrales P.


Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood
Ortiz D, Barros M, Yan S, and Cabrales P.


Microvascular shunts and hematocrit dispersion in microvascular f low
Sriram, K., Tartakovsky, D. M., Fagrell, B., lntaglietta, M.


Regulation of endothelial response to disturbed flow by epigenetic factor (DNA methylation)
Zhou J., Li, Y. S., Wang, K. C., Chien, S.


Treating pediatric obesity with technology assisted behavioral training
Salazar Vazquez, B. Y., Salazar Vazquez, M. A,. Cabrales, P., Perez Tamayo, R., lntaglietta, M., Schmid-Schtinbein, G. W.


Establishment of the sigma factor network in E. coli
Cho, Palsson, 8.0. , et al


Network definition of minimal pathway structure that is consistent with biomolecular interactions
Bordbar, A., Palsson, 8.0. , et al


Information theoretic approach to complex biological network reconstruction
Farangmehr, Maurya, Tartakovsky, Subramaniam


Time varying causal inference in macrophage cells
Masnardi-Shirazi, Maurya, Subramaniam


Statistical insights into major human muscle diseases
Gupta, Kim, Wang, Dinasarapu, Subramaniam


Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin
Castro C, Ortiz D, Palmer AF, and Cabrales P.


Microhemodynamic parameters quantification from intravital microscopy videos.
Ortiz D, Briceno JC, and Cabrales P.


2013

 

5th Bioengineering Chair
Dr. Geert Schmid-Schtinbein


14th UC System-Wide Bioengineering Symposium


NAVBO Vasculata Meeting


Transport of nitric oxide by perfluorocarbon emulsion
Ortiz D, Cabrales P, and Briceno JC.


Cerebral tissue oxygenation impairment during experimental cerebral malaria.
Cabrales P, Martins YC, Ong PK, Zanini GM, Frangos JA, and Carvalho lJ.


Microhemodynamic aberrations created by transfusion of stored blood
Yalcin 0, Ortiz D, Tsai AG, Johnson PC, and Cabrales P.


Demonstration that acute insulin resistance is due to proteol ytic cleavage of the insulin receptor by digestive enzymes
Delano, F. A, Schmid-Schtinbein, G. W.


Multi-strain reconstructions predict colonization sites and auxotrophy
Monk, J., Palsson, B.0., et al


Tattoo Electronics
Coleman, T.


Preclinical evidence that multiorgan failure in shock is due to autodigestion
Delano, F. A., Hoyt, D. B., Schmid-Schtinbein, G. W.


Genome-scale analysis of the enzyme promiscuity
Nam, Palsson, B.0. , et al


Computation of temperature dependency of E. coli growth
Chang, Palsson, B.0. , et al


Community structure analysis of gene interaction networks in Duchenne muscular dystrophy (hailed by an anonymous reviewer as a hall mark paper)
Narayanan, Subramaniam


A combined "Omics" study of macrophages (the first study that integrated transcriptomics, regulatory genomics and lipidomics in a mammalian cell)
Dinasarapu, Gupta, Maurya, Fahy, Min, Sud, Gersten, Glass, Subramaniam


The first Complement Database
Yang, Dinasarapu, Reis, DeAngelis, Ricklin, Subramaniam, lambris


Quantitative transcriptomics using designed primer-based amplification (the first RNA seq method that maps over 90o/o of the mammalian transcriptome with only 50 picograms of RNA)
Bhargava, Ko, Will ems, Mercola and Subramaniam


2012

 

New Bioengineering Faculty Dr. Peter Wang


 

New Bioengineering Faculty Dr. Sheng Zhong


Center for Multiscale Imaging of Living Systems Kickoff Symposium


NIAMS Training Grant, Predoctoral Training in Translational Musculoskeletal Research


Establishment of the "Biosystems Major" for Bioengineering UG Degree
Or. Shankar Subramaniam and the Department


Evolution of bioengineering at UC San Diego
Or. Shankar Subramaniam


Functional coherence of molecular networks
Book Eds. Koyuturk, Grama, Subramaniam, S.


NIH Common Funds Metabolomics Data Repository and Coordination
Grant Subramaniam, S.


Functional classification of skeletal muscle networks I and II (the first complete molecular skeletal muscle networks)
Wang, Winters, Subramaniam, S.


PEG-Albumin supra plasma expansion increases wall shear stress and expression of MCP-1
Hightower, C. M., Salazar Vazquez, B. Y., Acharya, S. A., Subramanian, S., lntaglietta, M.


Genome-scale analysis of the enzyme promiscuity
Nam, Palsson, 8.0. , et al


Neuromorphic silicon integrated circuit exceeds the nominal energy efficiency of synaptic transmission in the mammalian brain (1fJ of energy per synaptic operation)
Karakiewicz, R., Genov, R., Cauwenberghs, G.


Supra plasma expansion due to restoration of viscosity shear thinning
Sriram, K., Tsai, A. G., Cabrales, P., Acharya, S. A., Tartakovsky, 0. M., lntaglietta, M.


Integrated models of metabolism and full marcomolecular synthesis established
Lerman, J., Palsson, B.0. , et al


Stochastic operator-splitting method for reaction diffusion systems
Choi, Maurya, Tartakovsky, Subramaniam, S.


Gene expression measurements: variance modeling considerations
Subramaniam, S., Hsiao


Small-volume resuscitation from hemorrhagic shock with polymerized human serum al bu min
Messmer C, Yalcin 0, Palmer AF, and Cabrales P.


2011

 

New Bioengineering Faculty Dr. Christian Metallo


 

New Bioengineering Faculty Dr. Todd Coleman


Renewal of the NIH Bioinformatics Training Grant
Subramaniam, S.


International Research-intensive Center of Excellence (I-RICE) IEM & University Systems of Taiwan


Bioinformatics and systems biology of the lipidome (the first comprehensive review on the lipidome)
Subramaniam, S. and laboratory


3D nano-mechanics of the erythrocyte membrane skeletal network when helical actin protofilaments are wrapped around by Intertwined al3 spectrins
Sche, P., Vera, C., Sung, L.A.


Autodigestion and receptor cleavage as cause of cell dysfunction in diabetes and hypertension
Delano, F. A., Chen, A. Y., Wu, K-1 S., Tran, E. D., Rodrigues, S. F., Schmid­Schonbein, G. w.


Single RNAP mutations shown to reprogram the transcriptional regulatoy network in E. coli
Conrad, Palsson, B.0. , et al


How red blood cells may die: Shear and Ca2+ induced RGD externalization from ankyrin triggers aVl33 integrtn-mediated erythrophagocytosis
Peng, W., Sung, L.A.


Genome sequence of the CHO K1 cell line established


First patient-specific model of heart failure reported
Dr. McCulloch's Group


A global clustering algorithm to identify Inc RNA in mammalian cells
Garmire, Garmire, Huang, Yao, Glass, Subramaniam, S.


2010

UCSD Bioengineering Doctoral Program ranked first in nation by National Research Council


NHLBI Training Grant on Integrative Bioengineering of Heart, Vessels and Blood


Award of the NSF Science and Technology Center (the Science of Information) Life Sciences Subramaniam, S.


Whole blood precision measurements of protease activity
Lefkowitz, R. B., Schmid-Schonbein, G. w., Heller, M. J.


Development of non-contact electrodes for acquiring electrocardiography (ECG), electroencephalography (EEG), and other biopotentials
Chi, Y. M., Jung, T. P., Cauwenberghs, G.


Erythrocyte tropomodulin isoforms with and without the N-terminal actin binding domain
Yao, W., Sung, L.A.


Role of microRNA in flow-regulation of endothelial cell cycle and growth
Wang, K. C., Garmire, L. X., Young, A., Nguyen, P., Trinh, A., Subramaniam, S., Wang, N., Shyy, J. Y., Li, Y. S., Chien, S.


Prediction of off-target effects of drugs using genome-scale models
Chang, Palsson, 6.0. , et al


Blood pressure correlates with blood viscosity in diabetes type 1 children but not in normals
Salazar Vazquez, B. Y., Salazar Vazquez, M.A., lntaglietta, M., Cabrales, P.


Reconsturction of host-pathogen models: TB inside the lung mactophage
Bordbar, A., Palsson, 6.0. , et al


The mouse macrophage lipidome (the first complete lipidome of a mammalian cell)

The LIPID MAPS
Consortium, Subramaniam, S.


Stochastic hybrid modeling of intracellular calcium dynamics
Choi, Maurya, Tartakovsky, Subramaniam, S.


 

New Bioengineering Faculty Dr. Pedro Cabrales


 

New Bioengineering Faculty Dr. Ratnesh Lal

2000s

2009

Bilateral Symposium with National Yang Ming University


Inauguration of Siebel Foundation Scholars


 

New Bioengineering Faculty Dr. Gert Cauwenberghs


Challenges in computational systems biology
Maurya, Subramaniam, S.


Development of first cardiac specific, injectable hydrogel for treating myocardial infarction
Dr. Karen Christman (PhD Students: Jennifer Singelyn, Jessica DeQuach)


E-Tmod expressing horizontal cells in the retina experience greater stress-strain relationship than vertically oriented neurons
Yao, W., Sung, L. A.


Integration of protein structures into genome-scale models


Establishment of the transcriptional unit actritectyure in E.coli


Bivariate microarray analysis
Hsiao, Subramaniam, S.


Mechanisms of human insulin resistance (a hall mark study on deciphering responders and non-responders to TZD treatment of insulin resistance)
Sears, Hsiao, Hsiao, Yu, Courtney, Ofrecio, Chapman, Subramaniam, S.

2008

Inaugural Joan and Irwin Jacobs Professor of Systems Biology and Bioengineering
Subramaniam, S.


Community consensus model for yeast Nature biotech


Inauguration of the Institute of Engineering in Medicine


UCSD Chancellor's Excellence Award for Research
Subramaniam, S.


5th Bioengineering Chair
Dr. Shankar Subramaniam


New BE Faculty
Dr. Adam Engler


First genome-scale reconstruction of a regolon
Cho,B. K, Palsson, B.O.


Appointed Editor-in-Chief of the journal, Wiley Interdisciplinary Reviews in Systems Biology and Medicine
Subramaniam, S.


Reneweral of the NIH Glue Grant, LIPID MAPS
Subramaniam, S.

2007

First Bioengineering Day (BE Day)


New BE Faculty
Dr. Kun Zhang


New BE Faculty
Dr. Shyni Varghese


New BE Faculty
Dr. Karen Christman


Beneficial microvascular effects due to infusion of saturated CO solution
Hangai-Hoger, N., Tsai, A.G., Cabraels, P., Suematsu, M., Intaglietta, M.


Genome-scale metabolic model of Mycobacterium tuberculosis
Jamshidi, N., Palsson, B.O.


Diagnosic frequency ultrasound improves microcirculatory function in ischemia-reperfusion injury
Hightower, C.M., Intaglietta, M.


Lowered blood viscosity limits resuscitation in hemorrhagic shock and not lowered blood oxygen carrying capacity
Cabrales, P., Tsai, A.G., Intaglietta, M.


Genome-scale model of human metabolishm
Duarte, N.D., Palsson, B.O.


The neuroinformatics workbench
Moene, Subramaniam,S, Bjaalie


Systems Biology of macrophages
Maurya, Benner, Pradervand, Glass, Subramaniam, S.

2006

First Bioengineering Quiz Bowl (BQB)


The first publication on "how mammalian cells parse signals" and communicate: sigaling in macrophages
Pradervand, Maurya, Subramaniam, S.


Review of the Glue Grant, "The alliance for Cellular Signaling"
Subramaniam, S.


Renewal of the NIH Bioinformatics Training Grant
Director Subramaniam, S.


Elevated plasma viscosity increases perivascular nitric oxide concentration and microvascular perfusion
Tsai, A.G., Cabrales, P., Frangos, J.A., Buerk, D.G., Intaglietta, M.


Genome-scale models used to growth couple metabolite production
Fong,S.S, Burgard, A.P., Herring, C.D., Knight, E.M., Blattner, F.R., Maranas, C.D., Palsson, B.O.


Development of a novel extracellular matrix microarray for probing cellular differentiation


Development of a flourescence resonance energy transfer (FRET) technique to visualize the spatio-temporal characteristics of mechanical activation of Src.
Wang. Y., Botvinick, E.L., Zhao, Y., Berns, M., Usami, S., Tsien, R.Y., Chien,S.


Paradoxical hypertension following increased hematocrit and blood viscosity
Martini, J., Salazar, Vazquez, B.Y., Intaglietta, M.


Establishment of the HHMI Interfaces Graduate Training Program
Cotter, Maer, Guda, Saunders, and Subramaniam


Creation of the LIPDS MAPS proteome Database
Cotter, Maer, Guda, Saunders, Subramaniam, S.

2005

4th Bioengineering Chair
Dr. Andrew McCulloch

Bioengineering Research partnership on "Molecular Basis of Flow-induced Endothelial Reorganization"


Publication of the Book,"Databasing the brain: from Data to Knowledge"
Eds: Koslow, Subramaniam,S.


Publication of the Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics Vol 7,8
Ed. Subramaniam, S.


Elevated plasma viscosity increases perivascular nitric oxide concentration and microvascular perfusion
Tsai, A.G., Cabrales, P., Frangos, J.A., Buerk, D.G., Intaglietta,M.


Genome-scale models used to growth couple metabolite production
Fong,S.S., Burgard, A.P., Herring, C.D., Knight, E.M., Blattner, F.R., Maranas, C.D., Palsson, B.O.


Multiple expression states discovered following adaptive evolution to hte same phenotype
Fong,S.S., Joyce, A.J., Palsson, B.O.


Paradoxical hypotension following increased hematocrit and blood viscosity
Martini, J., Salazar Vazquez, B.Y., Intaglietta, M.


Development of a flourenscence resonance energy transfer (FRET) technique to vistualize the spatio-temporal characteristics of mechanical activation of Src.
Wang Y., Botvinik, E.L., Zhao, Y., Berns, M., Usami, S., Tsien, R.Y., Chien. S,


Development of a novel extracellular matrix microarray for probing cellular differentiation
Flaim, C.J., Chien, S., Bhatia, S.


The first comprehensive classification of lipids
Fahy, Subramaniam, and the LIPIDMAPS Consortium


pTARGET - a new method of prediciting protein subcelluar localization in eukaryotes
Guda, Subramaniam, S.

2004

Terminal lymphatics: the tissue "lethal corner"
Hangai-Hoger,N., Cabrales, P., Briceno, J-C, Tsai, A.G., Intaglietta,M.


Red Blood cell storage induces microvascular dysfunction in transfusion
Tsai, A.G., Cabrales, P., Intaglietta, M.


Genome-scale models predict the outcomes of hith-throughput growth screens
Covert, M.W., Knight, E.M., Reed, J.L., Herrgard, M.J., Palsson, B.O.


Establishment of first mitochondrial protein sequence database, mitoproteome
Cotter, Guda, Fahy, Subaramaniam, S.


MITOPRED: a genome scale method for prediction of nucleus-encoded mitochondrial proteins
Guda, Fahy, Subramaniam, S.


Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis
Avidor-Reiss, Maer, Koundakjian, Polyanovsky, Keil, Subramaniam, S, Zuker.


Variance-modeled posterior inference of microarray data
Hsiao, Worrall, Olefsky, Subramaniam, S.


Computational modeling reveals interplay between components of a GTPase-cycle module
Bornheimer, Maurya, Farquhar, Subramaniam, S.

2003

New Biogengineering Faculty
Dr. Gabriel Silva


New Biogengineering Faculty
Dr. John Watson


New Biogengineering Faculty
Dr. Trey Ideker


Multi-institutional NIH glue grant,"The LIPIDMAPS"
Subaramaniam, S


Completion of the Powell-Focht Bioengineering Hall


Measurement of oxygen consumption by microvessel
Tsai, A.G., Friesenecker,B., Buerk, D.G., Johnson,P.C., Intaglietta,M.


Development of PEG-hemoglobin as an oxgen carrying that targets anoxic tissue
Tsai, A.G., Vandegriff,K.D.,


Mystries solved: Why actin protofilaments are 37nm long, and why erythrocyte membrate skeletal networks are hexagonal
Sung,L.A., Vera, C.


First erythrocyte tropomodulin knock-out mouse model created and characterized
Chu,X., Chen, J., Vera, C., Sung,K.L.P., Sung, L.A.


The first 3D mechanical model of the junctional complex in the erythrocyte membrate skeletal network
Sung,L.A., Vera,C.


Genome-scale model of yeast metabolism
Famili, I., Forster, J., Nielsen, J., Palsson, B.O.


Moleduclar and mechanical bases of focal lipid accumulation in arterial wall
Chien,S.

2002

3rd Bioengineering Chair
Dr Shu Chien


New Biogengineering Faculty
Dr. Jeff Hasty


New Biogengineering Faculty
Dr. Xiaohua Huang


Incorporation of SNPs into whole cell models
Jamshidi, N., Wiback, S.J., Palsson, B.O.


First match of gene activity with biomechanial functions
Li,Z.J., Huang, W., Jiang, Z.L., Gregersen, H., Fung, Y.C.


Genome-scale models predict the outcome of adaptive evolution
Ibarra, R.U., Edwards, J.S., Palsson, B.O.


The Alliance for Cellular signaling: A nature highlight publication researchers in the AfCS
Subramaniam, S.


The Molecular Pages Database
Li,Ning, Hedley, Saunders, Chen, Tindill, Hannay, Subaramaniam, S.

2001

NIH Program Project Grant: Biomechanics
Dr.Schmid-Schoenbein


Von Liebig Center for Entrepreneurism and Techonology Advancement


New Bioengineering Faculty
Dr. Michael Heller


Incorporation of transcriptional regulation into genome scale models
Covert, M.W., Palsson, B.O.


Demonstration of a second valve system in lymphatics
Trzewik, J., Artmann, G.M., DeLano, F.A., Schmid-Schonbein,G.W.


Growth predictions of genome-scale models validated
Edwards, J.S., Ibrarra, R.U., Palsson, B.O.,


Award of the first NIH Bioinformatics Graduate Training Grant
Dr.Shankar Subramaniam


Multi-institutional NIH glue grant, "The Alliance for Cellular Signaling"
Dr.Shankar Subramaniam

2000

Bioengineering Research Partnership on "Molecular Basis of FLow-induced Endothelial Reorganization"


Bioengineering Research Partnership for the development of blood substitues
Dr. Marcos Intaglietta


Creation of the UCSD Bioinformatics and Systems Biology Graduate Program
Founding Director
Dr. Shankar Subramaniam


A complex formed by erythrocyte tropomodulin and rod-like tropomyosin 5 or 5b may function as a "molecular ruler"
Sung, L.A., et al.


First demonstration of organ failure by leaking pancreatic digestive enzymes
Misuoka, H., Kistler, E.B., Schmid-Schonbein, G.W.


Effect of red blood cell aggregation onn venular hemodynamics
Bishop, J.J., Popel, A.S., Johnson, P.C., Kim, S., Intaglietta, M.


Large molecular dimension hemoglobin oxygen carriers lower hypertensive effect
Sakai, H., Tsuchida, E., Intaglietta,M.


Genome-scale metabolic model established for E. coli
Edwards, J.S., Palsson, B.O.


Creation of the NIH BISTI White Paper, that led to the start of large scale NIH funding of biomedical informatics: The NIH Director's Advisory Committee on Biomedical Informatics
Dr. Shankar Subramanaiam


A novel microarray Strategy for detecting genes and pathways in microbes with unsequenced genomes
Ramarathnam, Subramaniam, S.

1990s

1999

Window Chamber analysis and ischemic tissue flaps in plastic surgery
Erni, D., Intaglietta, M.


First genome-scale metabolic model established for Hamophilus influenzae
Edwards,J.s., Palsson, B.O.


2nd Engineering chair
Dr. David Gough


New Bioengineering Faculty
Dr. Shankar Subramaniam

1998

Whitaker Foundation Leadership Award
Chien, S
Powell Foundation Award


Planning of Construction of Powell-Focht Bioengineering Hall


The extreme pathway structure of integrated networks established
Schilling, C.H., Palsson, B.O.


Novel Pseudo-pods described on hematopioetic stem cells
Francis, K., Holloway, W., Ramakrishna, R., Palsson, B.O.


The Beneficial effect of high plasma and blood viscosity
Tsai, A.G., Cabrales P., Martini, J., Intaglietta, M


Measurement of oxygen consumption by microvessels
Tsai, A.G., Friesenecker,B, Buerk, D.G., Intaglietta, M.

1997

Annual Meeting of Biomedical Engineering Society
Chien,S., Skalak, R.


Collaborative program: Development of artificial blood Dept. of Polymer Chemistry Waseda University, Tokyo, Japan, and Dept. of Bioengineering
Dr. Eishun Tsuchida, Dr. Marcos Intaglietta


Role of integrins in cellular responses to mechanical stress and adhesion
Shyy, J.Y.J., Chien, S.


Microvascular responses to hemodilution with Hb vesicles as red blood cell substitues
Sakai, H., Tsai, A.G., Hara, H. Takeoka, S., Tsuchida, E., Intaglietta, M.


First demonstration of fluid shear stress response in immune cells
Schmid-Schonbein, G.W.

1996

Development of first biomechanical model of myogenic response in arterioles
Lee, S-Y, Schmid-Schonbein, G.W.


Discovery of functional capillary density as determinant of survival, and not tissue oxygen tension in hemorrhage
Kerger,H., Saltzman, D.J., Messmer, K., Tsai, A.G., Friesenecker,B., Cabrales, P., Intaglietta,M.

1995

New Bioengineering Faculty
Dr. Bernhard Palsson


Studies of hemoglobin based blood substitues in the microcirculation
Tsai, A.G., Cabrales, P., Winslow, R.M., Intaglietta, M


Demonstration of pseudopod formation in capillary endothelium
Lee, J., Schmid-Schonbein, G.W.


Demonstration of the induction of inflammatory gene expression by a shear responsive cis elemenet
Shyy, Y.J., Lin, M.C., Han, J., Lu, Y., Petrime, M., Chien, S.

1994

Whitaker Foundation Development Award
Dr.Shu Chien


First Bioengineering Department in the UC System


Founding Bioengineering Chair
Dr. Shu Chien


New Bioengineering Faculty
Dr. L. Amy Sung


Establishment of "Molecular Biology Common Facility" in EBUI with the support of the Whitaker Foundation Development Award to Bioengineering
Founding Director: L. Amy Sung
The first female tenured or tenure-tracked faculty in the department.


Direct Visualization of oxygen free radicals in vivo
Suematsu, M. Tamatami, T., DeLano, F.A., Miyasaka, M., Schmid-Schonbein, G.W.


Erythrocyte tropomodulin binds to the N-terminal end of the rod-like tropomyosin 5 isoform
Sung, L.A., Lin, J.J. C.

1993

Whitaker Foundation Development Award and Industrial Liaison Program


Remodeling of the constitutive equation of a living tissue under stress
Fung, Y.C., Liu, S.Q., Zhou, J.B.

1992

Molecular cloning of erythrocyte tropomodulin: The first in a large family
Sung, L.A., Fowler, V.M., Lambert, K., Sussman, M.A., Karr, D., Chien,S


New Faculty
Dr. Robert Sah

1991

Demonstration of leukocyte obstruction of capillaries and no-reflow in stroke
Del Zoppo, G.J., Schmid-Schonbein, G.W.

1990

NIH Program Project Grant: "Biophysics of Blood Cells, Blood Vessels, and Microcirculation"
Chien,S


First World Congress of Biomechanics
Chien,S, Skalak, R.


Hyperosmotic fluid efficay in treating hemorrhage
Mazoni, M.C., Borgstrom, P.m Arfors, K-E, Intaglietta, M.


First Demonstration of residual strain in the heart
Omens, J.H., Fung, Y.C.


Molecular cloning of human erythrocyte membrane skeletal protein 4.2
Sung, L.A, Chien, S, Chang, L.S., et al.

1980s

1989

Tissue oxygenation by discrete sources(single file RBC flow)
Tsai, A.G., Intaglietta, M.

 

First application of non-harmonic analysis of semi-periodic cardiovascular phenomena: the Prony Spectral Line Estimator
Buckhard, P.M., Meyer, J-U, Secomb, T.W., Breit, G.A., Intaglietta,M.

1988

First Graduate Course on Molecular and Cellular Bioengineering
Chien S, Sung,K.L., Sung, L,A.


First theory of blood flow in skeletal msucle based on realistic topology and mechanical properties
Schmid-Schonbein, G.W.


Demonstration of residual stress in arteries
Liu, S.Q., Fung, Y.C.


Small value hypertonic resuscitation: microvasdcular consequences and role of endothelial swelling
mazzoni, M.C., Arfors, K-E, Easterbrook, M.H., Hargens, A.R., Intaglietta,M.


New Bioengineering Faculty
Dr. Shu Chien

1987

New Bioengineering Faculty
Dr. Andrew McCulloch

1986

First Bioengineering Graduate Symposium


Physics and physiology of hemodilution at the microvascular and systemic level from in vivo studies
Messmer,K., Mirhashemi, S., Bertuglia, S., Tsai, A.G., Cabrales, P., Intaglietta,M.

1985

First full reconstruction of the microvascular network in skeletal muscle
Engelson, E. T., Skalak, T. C. , Schmid-Schönbein, G. W.

1984

Demonstration for lymph formation by vasomotion
Skalak, T.C. Schmid-Schoenbein, G.W., Zweifach, B. W.


Demonstration of leukocyte capillary plugging in the heart
Engler, R.L., Schmid-Schonbein, G.W.

1983

Vasomotion as a factor in peripheral vascular resistance
Funk,W., Endrich, B., Messmer, K., Gross,J. F. , Bertuglia, S., Intaglietta, M.


First Time-dimensional stress distribution in arteries
Chuong, C.J., Fung, Y.C.

1982

Founding Dean of the Jacobs School Engineering
Dr. M. Lea Rudee

1981

First analysis of passive viscoelastic properties of human leukocytes
Schmid-Schönbein, G.W., Sung, K-L P., Tözeren,H., Chien,s, Skalak,R.


First precise morphometic analysis of leukocytes
Schmid-Schönbein, G.W., Shih, Y.Y., Chien,S.

1980

Tucson-San Diego Program Project:Quantative studies of microvascular function
Dr. Paul C. Johnson and Dr. Marcos Intaglietta


Discovery of microvascular pacemakers driving spontaneous time dependent activity of the microcirculation
Meyer, J-U, Bertuglia,S, Borgstrom, P, Xiu, RJ, Gross, JF, Schmidt, JA, Intaglietta,M

 

1970s

1979

Effects of perfluorocarbon as Blood Substitutes in the Microcirculation
Endrich, B. , Greenburg, A.S., Cabrales,P., Briceno, J.C., Chavez-Negrete,A., Intaglietta,M


First Consitutive Equation for Lung Tissue
Vawter,D.L., Fung, Y.C., West, J.B.
Perflurocarbons as Gas Transporters for O2,NO, CO, and Volatile Anesthetics
Cabrales,P., Salazar Vazquez, B.Y., Chavez-Negrete, A., Intaglietta,M

 


New Bioengineering Faculty
Dr. Geert Schmid-Schönbein

1977

Window Chamber Technique for In Vivo Hemodynamic Analysis of Tumor Microcirculation
Endrich, B. , Papenfuss,H.D, Gross, J.F. Reihold,H.D., Intaglietta,M.


Biomechanics of Active Smooth Muscle
Price, J.M. , Patitucci, P., Fung, Y.C.

 

1976

Biomechanics of an Exact microvascular Network
Lipowsky,H.h., Zweifach,B.W.


New Bioengineering Faculty
Dr.David Gough

1974
Capillary Blood flow and Pressure Measurements in Humans
Butti,P., Mahler, F., Bollinger,A., Anliker, M., Fagrell,B. , Fronek,A. Intaglietta,M.
Mechanical Properties of the Skin
Lanir,Y. Fung, Y.C.
1973

Developed at UC San Diego Bioengineering, 200 laboratories supplied worldwide, including instrumentation for Physiology and Medicine Inc., commercializes on-line dynamic microscopic measurement of flow, geometry and pressure in the microcirculation the USSR
Intaglietta,M.


Mechanical Properties of the Heart Muscle
Pinto, J.G. , Fung, Y.C.

 

1972

Renal Perfusion and Pulmonary Ventilation Measurements by Video Fluroscopy
Silverman,N.R., Intaglietta,M.


First Precise Measurements of the Erythrocyte Geometry
Evans,E., Fung, Y.C.

 

1971

First NIH Training Grant with Department of Surgery


Mechanical Properties of Mammalian Ureteral

Yin, F.C.P., Fung, Y.C.


Pediatric, Automated Heart Lung Machine for Infants

Turnia,M., Brauwald, N.S., Intaglietta,M.

1970
Instrumentation for On-Line Pressure and Flow Measurements in the Microcirculation Intaglietta,M.

1960s

1969

Bioengineering Faculty and Family
SheetFlow Theory in Pulmonary Circulation
Fung, Y.C., Tong,P., Sobin,S. S.

1968

Exponential Law for Elastic Response or Soft Living Tissue


Fung, Y.C.

Mechanics of fluid exchange in single, in-vivo blood capillaries

Zweifach, B.W., Intaglietta, M.

1967

Theory of the Sphering of Red Blood Cell

Fung, Y.C., Tong, P.

1966

Bioengineering is born at UC San Diego within the Department of Aerospace and Mechanical Engineering (AMES)

Founding Faculty.

Dr Yuan-Cheng Fung

Dr Benjamin Zweifach

Dr. Marcos Intaglietta

1965

Dr. Marcos Intaglietta visits the laboratory of Professor Peer Scholander at Scripps Oceanographic and organizes the subsequent visits of Dr. Benjamin W. Zweifach and finally Dr. Y. C. Fung.

The group meets with Professor S. Penner who proposes forming a multidisciplinary group in Bioengineering / Biomechanics in combination with the School of Medicine.