Boundaryless Innovation: Value Capture of Botulinum Neurotoxins (50th Anniversary Lecture)

Friday, February 5, 2016 - 2:00pm
Calit2 Auditorium | Atkinson Hall
Abhay Joshi, Ph.D., M.B.A.

Chief Operating Officer
Revance Therapeutics

Boundaryless Innovation: Value Capture of Botulinum Neurotoxins (50th Anniversary Lecture)


Clostridum botulinum, a spore-forming obligate anaerobic bacterium, produces seven distinctly serologically different (A, B, C, D, E, F, and G) Botulinum Neurotoxins (BoNTs). These BoNTs generate their potent toxic effects by presynaptic block of neurotransmitter release and thereby cause paralysis. Respected as the most potent toxins known, innovation across the drug development value chain has culminated in BoNTs as safe, efficacious and widely accepted therapeutic treatments for debilitating medical conditions including blepharospasm, strabismus, cervical dystonia, juvenile cerebral palsy, migraine and spasticity

Contrasting, BoNTs are equally poplular for aesthetic treatments of hyperfunctional facial lines. This presentation will discuss boundaryless innovation and the history of the BOTOX® drug development heralding the trajectory of toxins from “dreaded paralytic poisons” to “miracle medical and cosmetic aesthetic potions” using the speaker’s research, development, manufacturing and commercial interface experiences.

  • Over twenty five years leading global biologics, pharmaceuticals, and medical device organizations across the value chain.
  • Responsible for Allergan’s global biologics manufacturing operations for BOTOX® and its Latin America and Asia Pacific pharmaceutical operations.
  • Guest Lecturer for the BioExec Institute
    Haas School of Business, University of California, Berkeley
  • Adjunct Professor
    School of Pharmaceutical Sciences, University of Southern California

Previous Positions:

  • President and CEO
    Alvine Pharmaceuticals

  • Executive Vice President and Chief Technical Officer
    CoTherix, Inc. (acquired by Actelion Ltd, 2007)

  • Vice President of Global Technical Operations, Specialty Pharmaceuticals
    Allergan Inc


  • BTech in Chemical Engineering
    Indian Institute of Technology, New Delhi

  • MSE and a Ph.D. in Chemical Engineering
    University of Michigan, Ann Arbor, MI

  • MBA
    University of California, Irvine

Board Member:

  • Alvine Pharmaceuticals, Inc
  • Genyous Biomed International