Immuno-Imaging and Immunotherapy in Atherosclerosis
Director, Translational and Molecular Institute
Lucy G. Moses Professor in Medical Imaging and Bioengineering
Vice chair for Research, Department of Radiology
Professor of Medicine, Division of Cardiology
Icahn School of Medicine at Mount Sinai School, New York, NY
Immuno-Imaging and Immunotherapy in Atherosclerosis
The immune system’s role in atherosclerosis has long been an important research topic and is increasingly investigated for therapeutic and diagnostic purposes. Therefore, noninvasive imaging of hematopoietic organs and immune cells will undoubtedly improve atherosclerosis phenotyping and serve as a monitoring method for immunotherapeutic treatments. Positron emission tomography’s unique features make it an ideal tool to quantitatively image the immune response in the context of atherosclerosis and afford reliable readouts to guide medical interventions in cardiovascular disease. Here, I summarize the state of the art in the field of atherosclerosis PET immunoimaging and provide an outlook on current and future applications. I will also cover some of the possibilities of using nanobiologics for immunotherapy for the treatment of atherosclerosis.
Zahi A. Fayad, PhD serves as the Lucy G. Moses Professor of Medical Imaging and Bioengineering at the Icahn School of Medicine at Mount Sinai. He is Professor of Radiology (vice-chair for research) and Professor of Medicine (Cardiology). He is the founding Director of the Translational and Molecular Imaging Institute. Dr. Fayad’s research has been dedicated to the detection and prevention of cardiovascular disease with many seminal contributions in the field of multimodality biomedical imaging (MR, CT, PET and PET/MR) and nanomedicine. Recent collaborative work has been in: 1) the study of psychosocial stress exposure in the brain, the cardiovascular system and the immune system; 2) the development of platform nanotechnology to produce nanobiologics for immunotherapy in multiple disease conditions; 3) the development of the Mount Sinai Imaging Research Warehouse (de-identified, pseudo-anonymized images and metadata) as a unique repository of radiological imaging big data for focused imaging and general healthcare research.
He is Guest Editor for the Journal of the American College of Cardiology Imaging (JACC Imaging), Section Editor for Journal of the American College of Cardiology (JACC), Consulting Editor for Arteriosclerosis Thrombosis and Vascular Biology (ATVB), Guest Editor for the Journal of Cardiovascular Magnetic Resonance (JCMR) and past Associate Editor of Magnetic Resonance in Medicine (MRM). From 2013-2017, he served as Charter Member, NIH Center of Scientific Review, Clinical Molecular Imaging and Probe Development Study Section. In 2015, he chaired the Scientific Advisory Board of the Institut National de la Santé et de la Recherche Médicale (INSERM) PARCC program at the HEGP in Paris.
Dr. Fayad has authored more than 400 peer-reviewed publications (h-index of 110 accessed 08/01/2020 on Google Scholar with over 100,000 citations), 50 book chapters, and over 500 meeting presentations. He is currently the Principal Investigator of multiple federal, foundation and industry grants including 6 grants (5 R01s, 1 P01) funded by the National Institutes of Health’s National Heart, Lung and Blood Institute and National institute of Biomedical Imaging and Bioengineering. In 2019, Dr. Fayad ranked No. 4 in NIH research overall funding in the field of Radiology.
Dr. Fayad had his engineering trainings at Bradley University (BS, Electrical Engineering ’89), the Johns Hopkins University (MS, Biomedical Engineering ‘91), and at the University of Pennsylvania (PhD Bioengineering ’96). From 1996 to 1997 he was junior faculty in the Department of Radiology at the University of Pennsylvania. In 1997 he joined the faculty at the Mount Sinai School of Medicine as Assistant Professor in Radiology and Medicine (Cardiology).
As a teacher and mentor, Dr. Fayad has been also extremely successful. He has trained over 100 postdoctoral fellows, clinical fellows and students. His trainees have received major awards, fellowships, and positions in academia and industry.
Dr. Fayad is the recipient of multiple prestigious awards including, but not limited to Fellow American Heart Association (2001), British Medical Association Book Award (2004), Fellow American College of Cardiolgy (2005), the John Paul II Medal, Krakow Poland (2007), Outstanding Teacher Award from the International Society of Magnetic Resonance in Medicine (2008), Honorary Professor of Nanomedicine, Aarhus Univ, Denmark (2009), Opening speaker at the 97th Scientific Assembly and Scientific meeting of the Radiological Society of North America (2011), Henry I Russek Lecture at the 45th Anniversary of the ACCF New York Cardiovascular Symposium (2012), Fellow International Society of Magnetic Resonance in Medicine (2013), Academy Radiology Research Distinguised Investigator (2013), Distinguished Reviewer award from Magnetic Resonance in Medicine (2013), Centurion Society Medal from Bradley University (2014), the Editor’s Recognition Award, from the journal Radiology (2014), and the Lucy G. Moses Professor of Biogengeering & Medical Imaging (2015), Dr. Joseph Dvorkin Memorial Lecturer at the Cardiac Research Day of the Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada (2015), Heart & Stroke/Richard Lewar lecturer at the Center of Excellence in Cardiovascular Research in Toronto (2016), Dr. Fayad’s work on stress, the immune system and cardiovascular disease published in the Lancet was featured in the Altmetric Top 100 (2017), Highly Cited Researchers by Clarivate Analytics (2018, 2019), Mount Sinai Jacobi Medallion Award (2019).
He is married to Monique P. Fayad, MBA and is the proud father of Chloé (18 year old) and Christophe (14 year old) and after spending seven years in Manhattan now lives in Larchmont, runs in Central Park and participates regularly in New York Road Runners races. He also enjoys sailing and stand-up board paddling in Larchmont, New York, Connecticut, Rhode Island, Cape Cod, Martha’s Vineyard, Nantucket, the Caribbean Islands and beyond. He practices all type of daily fitness regimens that include strength (power and olympic lifting), cardiovascular, core, flexibility and high intensity interval trainings for fun.