Cartilage Tissue Engineering (Sah Lab)
Our research seeks to develop better ways of preventing, diagnosing, and treating diseases and injuries of cartilage. Osteoarthritis, for example, is a common disease in adults and especially those who have suffered a joint injury. However, osteoarthritis has no cure, and metal-and-plastic joint replacements do not fully restore joint function. To better understand the deterioration process in osteoarthritis, we perform experiments to clarify the molecular, cellular, tissue, and organ level processes involved in the disease. We develop and utilize biomechanical tests to determine how the joint tissues and lubricating fluids are altered, and how they may be treated. We work to translate therapeutic designs into industrial and clinical applications. We have active collaborations with researchers in Orthopaedic Surgery, Facial Plastic and Reconstructive Surgery, Rheumatology, and Radiology.