- About Us
- Current Students
- Prospective Students
- Contact Info
- Degree Programs
- Prospective Students
- Career Information
- Senior Design
- Travel Award
- Industry Central
- Careers and Internships
Postdoctoral Scholar positions are available according to the availability of funds and trainee vacancies in the UC San Diego Department of Bioengineering. Postdoctoral Employees are paid from the professor's research grant. Postdoctoral Fellows are paid from a National Institutes of Health (NIH) training grant. Both position types are under the mentorship of UC San Diego Bioenginereing faculty members.
None available at this time.
Bioinformatics Post Doctorate Research Associate
None available at this time.
Development of optical laser scissors and tweezers for the study of cell motility in a robotic and imaging mode.
Molecular mechanisms by which mechanical forces modulates signal transduction and gene expression.
Dr. Christman's research interests and expertise focus on the regeneration of injured and diseased cardiovascular tissues in vivo by making use of polymer chemistry and nanotechnology methods to develop novel biomaterials for tissue implantation and cell delivery. Dr. Christman's doctoral research was the first to recognize that appropriate biopolymers alone can affect post-myocardial infarction remodeling, both highlighting the importance of the physical and chemical properties of polymer scaffolds on tissue healing and showing the need for non-cellular controls in assessing the effects of cell-based therapies for myocardial infarction in vivo.
Research Areas: 1) Extracellular matrix regulation of embryonic and mesenchymal stem cell differentiation, 2) Developmental biology and mechanics of precardiac mesoderm, 3) Cell adhesion to 3-dimensional fibronectin matrix
Development and application of biochemical-specific senors.
Utilization of nonlinear dynamics and statistical physics in the design, construction and analysis of gene regulatory networks.
Development of high performance bioanalytical techniques and technologies for genomic, proteomic and phamacogenomic applications.
Genomics, molecular biotechnology and bioinformatics including chemistry and biophysics of protein and DNA molecules and technologies.
Evolutionary comparison of protein interaction networks; Modeling the gene regulatory and protein signaling networks responding to DNA damage.
Development of new blood substitute using modified hemoglobin. Mechanism of microcirculatory regulation.
Rheological properties of blood in vivo, local and neural mechanisms of blood flow regulation in the microcirculation, oxidative metabolism-blood flow relations and development of instrumentation for microcirculatory research.
In-vivo, in vitro and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and electrical and mechanical function of the normal and diseased heart. Tissue engineering for cardiac regeneration. Systems biology approaches to cardiac genotype-phenotype relationships.
Reconstruction of genome scale networks (metabolic, regulatory and signaling). Mathematical assessment of their properties and experimental determination of their functions. Systems Biology.
Tissue engineering for functional restoration of cartilage and diarthrodial joints. Multiscale mechanobiology of cartilage in growth, aging, and osteoarthritis. Lubrication biomechanics of articular cartilage. Biomechanical and biochemical regulation of chondrocyte and matrix metabolism.
Use of experimental and mathematical tools of bioengineering to identify the mechanisms for important cardiovascular diseases and microcircualtion. Molecular analysis of the auto-digestion hypothesis for organ failure.
Systems neuroscience and applied nanotechnology for investigating intercellular signaling in the central nervous system under physiologically normal conditions and following disease integrated across spatial scales, from individual cells to large neural cell networks.
Bioinformatics and Systems Biology. Networks and phenotypes for mammalian biology.
Molecular structure, genomic organization and control of gene expression of membrane skeletal proteins in relation to mechanical properties of cells and tissues. Targeted disruption of genes and disease phenotypes. Intrrinsic helix and external ruler mechanisms for actin protofilament length control. 3-D model of a juctional complex where spectrin and actin meet. The topology and 3-D dynamics of the membrane skeleton. Biomechanics of DNA and nucleosomes. Mechanical and immunological bases of cell death in human.
Dr. Varghese's interests and expertise lie in the application of novel and rational biomaterials design and synthesis to the repair and regeneration of injured and diseased tissues, especially for developing stem cell-based therapies for musculoskeletal defects. Her interests lie at the interface between stem cell biology, cell-matrix interactions, and molecularly engineered biopolymers for regulating stem cell fate and commitment, and regenerative medicine.
Translating benefits to patients more efficiently, activities leading to policies and incentives that reduce the number of years from conception of a new medical innovation until it reaches general clinical use and commercialization.
With his diverse interdisciplinary training in biophysics, neuroscience, genomics and human genetics, Dr. Zhang's research has focused on the development and application of new genome technologies, with an emphasis now on stem cell research and personalized medicine.