Fung Auditorium, Powell-Focht Bioengineering Hall
Dr. Frederic Kolb, M.D.
University Hospital and Oncologic Center Gustave Roussy, Paris
Tracheal Reconstruction, When Surgery Meets Bioengineering
Tracheal replacement has been and still remains a surgical challenge. Today, partial resection, up to half of tracheal length, is a well-codified surgery and can be repaired by mobilization of the remaining tracheal stumps and direct suture. However, despite numerous proposed solutions, no valid technic have been described to allow the replacement of more than 1/2 of the trachea.
Recently, several breakthroughs have brought new hopes and may help us to consider that a definitive solution is at hand. Three main solutions drive a special attention because of their promising character. The first one, presented by Deleare and al, uses a tracheal allograph. The second relies on a complete bioengineered decellularized, recellularized trachea. Finally, our team proposed an autologous solution based on a buttressed forearm free flap.
Despite the hope brought by these advances, none is ideal and matches all 5 Grillo's requirements. Our solution fulfills 3 of them but fails to bring a ciliary epithelium, and lack reproducibility. We started a program of research, which goal is to correct these 2 weaknesses through the use of bioengineering and to obtain a chimeric construct combining autologous tissues with bioengineered ciliary epithelium and cartilage rings. We considerer this solution as an intermediary but obligatory step before a complete bioengineered trachea can be created.
Born in 1963 in Paris. Trained at the University of Medicine of Paris. Graduated in 1990. Master II in Sciences on biomaterial in 1993. Obtained his plastic surgery board in 1997. Appointed as Plastic Surgeon in the head and Neck department at the Oncologic Center of Gustave Roussy (Paris) in 1998. Became Chief of the department of Plastic Surgery of Gustave Roussy in 2011.